The -44 C/G (rs1800972) polymorphism of the β-defensin 1 is associated with increased risk of developing type 2 diabetes mellitus.

ABSTRACT:

Background

The aim of this study was to establish the association of two polymorphisms of the β-defensin 1 gene (DEFB1, OMIM#602056) with the risk of developing type 2 diabetes mellitus (T2DM) in a group of Mexican patients.

Methods

The 5'UTR -20 G/A, and -44 C/G polymorphisms of DEFB1 gene were genotyped by 5' exonuclease TaqMan assays in a group of 252 patients with T2DM and 522 healthy control.

Results

Under dominant and additive models adjusted for the risk factors, the C allele of the -44 C/G polymorphism was associated with increased risk of T2DM (OR = 1.63, 95% CI = 1.07-2.48, pC_dom  = 0.021 and OR = 1.42, 95% CI = 1.05-1.91, pC_add  = 0.023, respectively). In addition, the linkage disequilibrium analysis showed that AC haplotype was associ

SUBMITTER: Martinez-Rios MA 

PROVIDER: S-EPMC6382445 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature