Ocular phenotypic consequences of a single copy deletion of the Yap1 gene (Yap1 ^+/-) in mice.

ABSTRACT:

Purpose

To identify the effects of a single copy deletion of Yap1 (Yap1 ^+/-) in the mouse eye, the ocular phenotypic consequences of Yap1 ^+/- were determined in detail.

Methods

Complete ophthalmic examinations, as well as corneal esthesiometry, the phenol red thread test, intraocular pressure, and Fourier-domain optical coherence tomography were performed on Yap1 ^+/- and age-matched wild-type (WT) mice between eyelid opening (2 weeks after birth) and adulthood (2 months and 1 year after birth). Following euthanasia, enucleated eyes were characterized histologically.

Results

Microphthalmia with small palpebral fissures, corneal fibrosis, and reduced corneal sensation were common findings in the Yap1

SUBMITTER: Kim S 

PROVIDER: S-EPMC6382475 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature