Cognition and Cerebral Infarction in Older Adults After Surgical Aortic Valve Replacement.

ABSTRACT:

Background

Aortic valve replacement (AVR) for calcific aortic stenosis is associated with high rates of perioperative stroke and silent cerebral infarcts on diffusion-weighted magnetic resonance imaging (MRI), but cognitive outcomes in elderly AVR patients compared with individuals with cardiac disease who do not undergo surgery are uncertain.

Methods

One hundred ninety AVR patients (mean age 76 ± 6 years) and 198 non-surgical participants with cardiovascular disease (mean age 74 ± 6 years) completed comprehensive cognitive testing at baseline (preoperatively) and 4 to 6 weeks and 1 year postoperatively. Surgical participants also completed perioperative stroke evaluations, including postoperative brain MRI. Mixed model analyses and reliable change scores examined cognitive

SUBMITTER: Giovannetti T 

PROVIDER: S-EPMC6382522 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature