Coexistent Helminth Infection-Mediated Modulation of Chemokine Responses in Latent Tuberculosis.

ABSTRACT: Coexistent helminth infections are known to modulate T cell and cytokine responses in latent infection with Mycobacterium tuberculosis However, their role in modulating chemokine responses in latent tuberculosis (LTB) has not been explored. Because chemokines play a vital role in the protective immune responses in LTB, we postulated that coexistent helminth infection could modulate chemokine production in helminth-LTB coinfection. To test this, we measured the levels of a panel of CC and CXC chemokines at baseline and following mycobacterial Ag or mitogen stimulation in individuals with LTB with (Strongyloides stercoralis ⁺LTB⁺) or without S. stercoralis (S. stercoralis ^-LTB⁺) infection and in individuals without both

SUBMITTER: Rajamanickam A 

PROVIDER: S-EPMC6382527 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature