Polychlorinated biphenyls influence on autism spectrum disorder risk in the MARBLES cohort.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is suspected to have environmental and genetic contributions. Polychlorinated biphenyls (PCBs) are environmental risk factors of interest due to their potential as neurodevelopmental toxicants and environmental persistence despite a US production ban in the 1970s.

Methods

Participants were mother-child pairs from MARBLES, a high-risk pregnancy cohort that enrolls families who have one child diagnosed with ASD and are planning to have another child. PCB concentrations were measured in maternal blood at each trimester of pregnancy using gas chromatography coupled with triple quadruple mass spectrometry. Concentrations were summed into total PCB and two categories based on function/mechanisms of action: dioxin-like (DL), and ryanodine r

SUBMITTER: Granillo L 

PROVIDER: S-EPMC6382542 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature