Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women.

ABSTRACT:

Importance

Colorectal cancer (CRC) incidence and mortality among individuals younger than 50 years (early-onset CRC) are increasing. The reasons for such increases are largely unknown, although the increasing prevalence of obesity may be partially responsible.

Objective

To investigate prospectively the association between obesity and weight gain since early adulthood with the risk of early-onset CRC.

Design, setting, and participants

The Nurses' Health Study II is a prospective, ongoing cohort study of US female nurses aged 25 to 42 years at study enrollment (1989). A total of 85 256 women free of cancer and inflammatory bowel disease at enrollment were included in this analysis, with follow-up through December 31, 2011. Validated anthropomorphic measures and lifestyl

SUBMITTER: Liu PH 

PROVIDER: S-EPMC6382547 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature