Induction Radiation Therapy for Esophageal Cancer: Does Dose Affect Outcomes?

ABSTRACT:

Background

Wide variation is seen in the dosage of preoperative induction radiation therapy for esophageal cancer. We investigated associations between outcomes after esophagectomy and dosage of induction radiation therapy.

Methods

Patients undergoing induction radiation therapy (30 to 70 Gy), followed by esophagectomy, were identified from the National Cancer Database and classified as low (<40 Gy), standard (40 to 50.4 Gy), and high dose (>50.4 Gy). Perioperative outcomes and overall survival were compared. Subgroup analysis compared two common dosages: 45 Gy and 50.4 Gy.

Results

From 2004 to 2014, 10,738 patients (84.7%) received standard-dose radiation, increasing from 69.7% in 2004 to 93.6% in 2014 (p < 0.001), 1,329 (10.5%) received low-dose radiation, and 608 (

SUBMITTER: Semenkovich TR 

PROVIDER: S-EPMC6382550 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature