Temporal Changes in the Impact of HLA Mismatching Among Pediatric Kidney Transplant Recipients.

ABSTRACT: BACKGROUND:Allocation for pediatric deceased-donor kidney transplantation (pDDKT) in the United States now de-emphasizes HLA matching to improve equality in access to transplantation, but other national systems still consider HLA matching due to concerns about graft survival. We hypothesized that the impact of HLA mismatching has decreased over time due to advances including improved immunosuppression. METHODS:Using Scientific Registry of Transplant Recipient data, we analyzed whether the association between the number of HLA mismatches and outcomes of first-time pDDKTs changed between 2 eras: 1995 to 2004 (N = 2854) and 2005 to 2014 (N = 4643). RESULTS:Between eras, the median number of mismatches increased from 4 to 5 (P < 0.001). Overall graft failure risk was higher among HLA-mismatche

SUBMITTER: Ruck JM 

PROVIDER: S-EPMC6382603 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature