Comparison of Open-Source Reverse Vaccinology Programs for Bacterial Vaccine Antigen Discovery.

ABSTRACT: Reverse Vaccinology (RV) is a widely used approach to identify potential vaccine candidates (PVCs) by screening the proteome of a pathogen through computational analyses. Since its first application in Group B meningococcus (MenB) vaccine in early 1990's, several software programs have been developed implementing different flavors of the first RV protocol. However, there has been no comprehensive review to date on these different RV tools. We have compared six of these applications designed for bacterial vaccines (NERVE, Vaxign, VaxiJen, Jenner-predict, Bowman-Heinson, and VacSol) against a set of 11 pathogens for which a curated list of known bacterial protective antigens (BPAs) was available. We present results on: (1) the comparison of criteria and programs used for the selection of PVC

SUBMITTER: Dalsass M 

PROVIDER: S-EPMC6382693 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature