Phase I and phase II clinical trials in sarcoma: Implications for drug discovery and development.

ABSTRACT:

Background

There has been limited progress in the development of novel therapeutics for the treatment of sarcomas. A review of phase I and II clinical trials for sarcomas may give insight into factors influencing sarcoma drug development.

Methods

An exhaustive analysis of phase I and II clinical trials testing drugs for human sarcoma patients between 1 January 2000 and 1 June 2018 was performed using the PubMed search engine, the Thomson Web of Science, and the National Clinical Trials registry. Recorded outcomes included tested drugs, tested histological subtypes, whether the drug was initially developed for sarcoma, reported funding sources, and whether studies led to phase III trials.

Results

Out of 238 studies meeting inclusion criteria, 87% (207 studies) reported

SUBMITTER: Lee DY 

PROVIDER: S-EPMC6382713 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature