Revealing the Hippocampal Connectome through Super-Resolution 1150-Direction Diffusion MRI.

ABSTRACT: The hippocampus is a key component of emotional and memory circuits and is broadly connected throughout the brain. We tracked the whole-brain connections of white matter fibres from the hippocampus using ultra-high angular resolution diffusion MRI in both a single 1150-direction dataset and a large normal cohort (n = 94; 391-directions). Using a connectomic approach, we identified six dominant pathways in terms of strength, length and anatomy, and characterised them by their age and gender variation. The strongest individual connection was to the ipsilateral thalamus. There was a strong age dependence of hippocampal connectivity to medial occipital regions. Overall, our results concur with preclinical and ex-vivo data, confirming that meaningful in vivo characterisation of hippocampal conn

SUBMITTER: Maller JJ 

PROVIDER: S-EPMC6382767 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature