Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.

ABSTRACT: Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asth

SUBMITTER: Daya M 

PROVIDER: S-EPMC6382865 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature