Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress.

ABSTRACT: Tumor growth and progression is characteristically associated with the synergistic effects of uncontrolled cellular proliferation and cell survival under stress. Pyruvate kinase M2 (PKM2) contributes to both of these effects. However, the specific mechanism by which PKM2 promotes uncontrolled proliferation or cell survival under stress in different nutritional environments is unclear. We show that succinylation mediated mitochondrial translocation of PKM2 under glucose starvation plays a role in switching the cellular machinery from proliferation to cell survival mode and vice versa. Mitochondrial PKM2 inhibits ubiquitination-mediated degradation of voltage-dependent anion channel 3 (VDAC3) and increases mitochondrial permeability to generate more ATP for cell survival under nutritional de

SUBMITTER: Qi H 

PROVIDER: S-EPMC6382874 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature