Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.

ABSTRACT: The robust specification of organ development depends on coordinated cell-cell communication. This process requires signal integration among multiple pathways, relying on second messengers such as calcium ions. Calcium signaling encodes a significant portion of the cellular state by regulating transcription factors, enzymes, and cytoskeletal proteins. However, the relationships between the inputs specifying cell and organ development, calcium signaling dynamics, and final organ morphology are poorly understood. Here, we have designed a quantitative image-analysis pipeline for decoding organ-level calcium signaling. With this pipeline, we extracted spatiotemporal features of calcium signaling dynamics during the development of the Drosophila larval wing disc, a genetic model for organogenes

SUBMITTER: Brodskiy PA 

PROVIDER: S-EPMC6382932 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature