EnDisease: a manually curated database for enhancer-disease associations.

ABSTRACT: Genome-wide association studies have successfully identified thousands of genomic loci potentially associated with hundreds of complex traits in the past decade. Nevertheless, the fact that more than 90% of such disease-associated variants lie in non-coding DNA with unknown functional implications has been appealing for advanced analysis of plenty of genetic variants. Toward this goal, recent studies focusing on individual non-coding variants have revealed that complex diseases are often the consequences of erroneous interactions between enhancers and their target genes. However, such enhancer-disease associations are dispersed in a variety of independent studies, and thus far it is still difficult to carry out comprehensive downstream analysis with these experimentally supported enhancer-

SUBMITTER: Zeng W 

PROVIDER: S-EPMC6382991 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature