Non-sinusoidal Waveform in Temperature-Compensated Circadian Oscillations.

ABSTRACT: Time series of biological rhythms are of various shapes. Here, we investigated the waveforms of circadian rhythms in gene-protein dynamics using a newly developed, to our knowledge, index to quantify the degree of distortion from a sinusoidal waveform. In general, most biochemical reactions accelerate with increasing temperature, but the period of circadian rhythms remains relatively stable with temperature change, a phenomenon known as "temperature compensation." Despite extensive research, the mechanism underlying this remains unclear. To understand the mechanism, we used transcriptional-translational oscillator models for circadian rhythms in the fruit fly Drosophila and mammals. Given the assumption that reaction rates increase with temperature, mathematical analyses revealed that temp

SUBMITTER: Gibo S 

PROVIDER: S-EPMC6383000 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature