Increased myocardial sodium signal intensity in Conn's syndrome detected by 23Na magnetic resonance imaging.

ABSTRACT:

Aims

Sodium intake has been linked to left ventricular hypertrophy independently of blood pressure, but the underlying mechanisms remain unclear. Primary hyperaldosteronism (PHA), a condition characterized by tissue sodium overload due to aldosterone excess, causes accelerated left ventricular hypertrophy compared to blood pressure matched patients with essential hypertension. We therefore hypothesized that the myocardium constitutes a novel site capable of sodium storage explaining the missing link between sodium and left ventricular hypertrophy.

Methods and results

Using 23Na magnetic resonance imaging, we investigated relative sodium signal intensities (rSSI) in the heart, calf muscle, and skin in 8 PHA patients (6 male, median age 55 years) and 12 normotensive healthy co

SUBMITTER: Christa M 

PROVIDER: S-EPMC6383057 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature