Plasma microRNAs Predict Chemoresistance in Patients With Metastatic Breast Cancer.

ABSTRACT:

Background

MicroRNAs contribute to chemotherapy response in different types of cancer. We hypothesized that plasma miRNAs are potentially associated with chemotherapy response in patients with metastatic breast cancer.

Patients and methods

Fourteen candidate microRNAs were chosen from the literature, and their plasma levels were measured by quantitative polymerase chain reaction (PCR). Forty metastatic breast cancer patients were chosen as the training groups. The potential significant microRNAs were validated in another 103 plasma samples.

Results

In the training set, we identified 3 microRNAs (miR-200a, miR-210, and miR-451) as significantly dysregulated miRNAs between sensitive group (partial response (and stable disease) and resistant group (progressive disease).

SUBMITTER: Shao B 

PROVIDER: S-EPMC6383099 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature