Digital Technology in Somatic and Gene Therapy Trials of Pediatric Patients With Ocular Diseases: Protocol for a Scoping Review.

ABSTRACT:

Background

Pharmacogenomics suggests that diseases with similar symptomatic presentations often have varying genetic causes, affecting an individual patient's response to a specific therapeutic strategy. Gene therapies and somatic cell therapies offer unique therapeutic pathways for ocular diseases and often depend on increased understanding of the genotype-phenotype relationship in disease presentation and progression. While demand for personalized medicine is increasing and the required molecular tools are available, its adoption within pediatric ophthalmology remains to be maximized in the postgenomic era.

Objective

The objective of our study was to address the individual hurdles encountered in the field of genomic-related clinical trials and facilitate the uptake of pers

SUBMITTER: Meinert E 

PROVIDER: S-EPMC6383115 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature