EDetect: A Fast Error Detection and Correction Tool for Live Cell Imaging Data Analysis.

ABSTRACT: Live cell imaging has been widely used to generate data for quantitative understanding of cellular dynamics. Various applications have been developed to perform automated imaging data analysis, which often requires tedious manual correction. It remains a challenge to develop an efficient curation method that can analyze massive imaging datasets with high accuracy. Here, we present eDetect, a fast error detection and correction tool that provides a powerful and convenient solution for the curation of live cell imaging analysis results. In eDetect, we propose a gating strategy to distinguish correct and incorrect image analysis results by visualizing image features based on principal component analysis. We demonstrate that this approach can substantially accelerate the data correction proces

SUBMITTER: Han H 

PROVIDER: S-EPMC6383125 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature