Adherence to long-term use of renin-angiotensin II-aldosterone system inhibitors in children with chronic kidney disease.

ABSTRACT:

Background

Although renin-angiotensin II-aldosterone system inhibitor (RASI) use for renal protection is well-documented, adherence to RASI therapy in the pediatric population is unclear. This study aimed to evaluate patient characteristics associated with adherence to chronic RASI use in patients with childhood chronic kidney disease (CKD).

Methods

Childhood CKD was identified using ICD-9 codes in the population-based, Taiwan national health insurance research database between 1997 and 2011. Patients continuously receiving RASIs for ≥3 months without interruption > 30 days after CKD diagnosis were defined as incident users. Medication adherence was measured as the proportion of days covered (PDC) by RASI prescription refills during the study period. Multivariate logistic re

SUBMITTER: Hsu CN 

PROVIDER: S-EPMC6383266 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature