Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease.

ABSTRACT:

Background

To investigate how serum neurofilament light (NfL) concentration changes through the course of disease in familial Alzheimer's disease (FAD) and to assess when NfL concentration first increases.

Methods

NfL was measured using an ultrasensitive immunoassay in 117 serum samples from 61 individuals from families with PSEN1 or APP mutations in a longitudinal study (mean ± SD = 1.9 ± 1.1 visits/patient; inter-visit interval = 1.8 ± 1.1 years). The relationship between NfL concentration and estimated years to/from symptom onset (EYO) was modelled using linear regression, including all time points and robust standard errors to allow for repeated measurements, adjusting for age at visit and sex. Also, for the 27 participants who became symptomatic (during or before the st

SUBMITTER: Weston PSJ 

PROVIDER: S-EPMC6383280 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature