Calcium electroporation for recurrent head and neck cancer: A clinical phase I study.

ABSTRACT:

Background

Calcium electroporation is a novel cancer treatment, which combines temporary cell permeability from electroporation with a high influx of calcium intracellularly resulting in cancer cell necrosis.

Methods

A phase I trial performing calcium electroporation on 6 patients suffering from recurrent head and neck cancer. In general anesthesia, intratumoral calcium injections were followed by electroporation. Safety was monitored by adverse events registration, serum Ca²⁺, ECG, and pain scores. Tumor response was measured on PET/MRI scans.

Results

Procedures were performed without complications. No serious adverse events, signs of hypercalcemia, or cardiac arrhythmias were observed. Two months post-treatment tumor responses on MRI: three partial respon

SUBMITTER: Plaschke CC 

PROVIDER: S-EPMC6383303 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature