Catalytic activation of unstrained C(aryl)-C(aryl) bonds in 2,2'-biphenols.

ABSTRACT: Transition metal catalysis has emerged as an important means for C-C activation that allows mild and selective transformations. However, the current scope of C-C bonds that can be activated is primarily restricted to either highly strained systems or more polarized C-C bonds. In contrast, the catalytic activation of non-polar and unstrained C-C moieties remains an unmet challenge. Here we report a general approach for the catalytic activation of the unstrained C(aryl)-C(aryl) bonds in 2,2'-biphenols. The key is to utilize the phenol moiety as a handle to install phosphinites as a recyclable directing group. Using hydrogen gas as the reductant, monophenols are obtained with a low catalyst loading and high functional group tolerance. This approach is also applied to the synthesis of 2,3,4-tr

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6383370 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature