The correlation of p22^phox and chemosensitivity in EGFR-TKI resistant lung adenocarcinoma.

ABSTRACT:

Background

Enhancing the chemosensitivity in the patients with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistant lung adenocarcinoma (LUAD) is pivotal in achieving their successful therapeutic outcome. We aimed to explore the mechanisms regarding the development of therapeutic resistance to chemotherapy in EGFR-TKI resistant LUAD. Methods: Microarray analysis lead to potential involvement of p22^phox, which was abundantly expressed in the cell lines harboring EGFR-TKI resistance and chemoresistance, and was known to regulate several important chemoresistance-associated factors such as hypoxia inducible factor-1α (HIF-1α) and epithelial-mesenchymal transition (EMT). We compared the status of p22^phox with that of chemoresistance, HIF

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC6383684 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature