Evolutionary epidemiology models to predict the dynamics of antibiotic resistance.

ABSTRACT: The evolution of resistance to antibiotics is a major public health problem and an example of rapid adaptation under natural selection by antibiotics. The dynamics of antibiotic resistance within and between hosts can be understood in the light of mathematical models that describe the epidemiology and evolution of the bacterial population. "Between-host" models describe the spread of resistance in the host community, and in more specific settings such as hospitalized hosts (treated by antibiotics at a high rate), or farm animals. These models make predictions on the best strategies to limit the spread of resistance, such as reducing transmission or adapting the prescription of several antibiotics. Models can be fitted to epidemiological data in the context of intensive care units or hospit

SUBMITTER: Blanquart F 

PROVIDER: S-EPMC6383707 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature