Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this.

Objective

To explore the in vivo relationships between MRS and PET [¹¹C]PBR28 in MS over a range of brain inflammatory burden.

Methods

A total of 23 patients were studied. TSPO PET imaging with [¹¹C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability was assessed by Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC).

Results

[¹¹C]PBR28 uptake and [ m

SUBMITTER: Datta G 

PROVIDER: S-EPMC6383749 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature