Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course.

ABSTRACT: Disrupted sleep is a contributing factor to cognitive ageing, while also being associated with neurodegenerative disorders. Little is known, however, about the relation of sleep and the gradual cognitive changes over the adult life course. Sleep electroencephalogram (EEG) patterns are potential markers of the cognitive progress. To test this hypothesis, we assessed sleep architecture and EEG of 167 men born in the Copenhagen Metropolitan Area in 1953, who, based on individual cognitive testing from early (~18 years) to late adulthood (~58 years), were divided into 85 subjects with negative and 82 with positive cognitive change over their adult life. Participants underwent standard polysomnography, including manual sleep scoring at age ~58 years. Features of sleep macrostructure were combin

SUBMITTER: Waser M 

PROVIDER: S-EPMC6383751 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature