Impact of Abnormal Coronary Reactivity on Long-Term Clinical Outcomes in Women.

ABSTRACT:

Background

Currently as many as one-half of women with suspected myocardial ischemia have no obstructive coronary artery disease (CAD), and abnormal coronary reactivity (CR) is commonly found.

Objectives

The authors prospectively investigated CR and longer-term adverse cardiovascular outcomes in women with and with no obstructive CAD in the National Heart, Lung, and Blood Institute-sponsored WISE (Women's Ischemia Syndrome Evaluation) study.

Methods

Women (n = 224) with signs and symptoms of ischemia underwent CR testing. Coronary flow reserve and coronary blood flow were obtained to test microvascular function, whereas epicardial CR was tested by coronary dilation response to intracoronary (IC) acetylcholine and IC nitroglycerin. All-cause mortality, major adverse ca

SUBMITTER: AlBadri A 

PROVIDER: S-EPMC6383781 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature