Effects of highly active antiretroviral therapy on semen parameters of a cohort of 770 HIV-1 infected men.

ABSTRACT:

Background

HIV-1 infected patients show impaired semen parameters. Currently, it is not clear whether HIV-1 infection itself or antiretroviral therapy have an effect on semen parameters. We aim evaluate semen quality in a large cohort of fertile HIV-1 infected men under stable highly active antiretroviral therapy (HAART) and to assess the effect of HAART type and duration on semen parameters.

Materials and methods

Between January 2010 and June 2014, we enrolled in a retrospective case-control study 770 HIV-1 patients under stable HAART asking a reproductive counselling with their HIV negative partner. Co-infections with HBV or HCV, genital tract infections and known causes of infertility represented exclusion criteria. Semen samples were analysed and compared with the WHO re

SUBMITTER: Savasi V 

PROVIDER: S-EPMC6383866 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature