Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.

ABSTRACT: Microglia are resident immune cells that play critical roles in maintaining the normal physiology of the central nervous system (CNS). Remarkably, microglia have an intrinsic capacity to repopulate themselves after acute ablation. However, the underlying mechanisms that drive such restoration remain elusive. Here, we characterized microglial repopulation both spatially and temporally following removal via treatment with the colony stimulating factor 1 receptor (CSF1R) inhibitor PLX5622. We show that microglia were replenished via self-renewal, with no contribution from nonmicroglial lineages, including Nestin+ progenitors and the circulating myeloid population. Interestingly, spatial analyses with dual-color labeling revealed that newborn microglia recolonized the parenchyma by forming dis

SUBMITTER: Zhan L 

PROVIDER: S-EPMC6383943 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature