Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesis.

ABSTRACT: Gonad differentiation is a crucial step conditioning the future fertility of individuals and most of the master genes involved in this process have been investigated in detail. However, transcriptomic analyses of developing gonads from different animal models have revealed that hundreds of genes present sexually dimorphic expression patterns. DMXL2 was one of these genes and its function in mammalian gonads was unknown. We therefore investigated the phenotypes of total and gonad-specific Dmxl2 knockout mouse lines. The total loss-of-function of Dmxl2 was lethal in neonates, with death occurring within 12 hours of birth. Dmxl2-knockout neonates were weak and did not feed. They also presented defects of olfactory information transmission and severe hypoglycemia, suggesting that their prematu

SUBMITTER: Gobe C 

PROVIDER: S-EPMC6383954 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature