New Isolates of Pandoraviruses: Contribution to the Study of Replication Cycle Steps.

ABSTRACT: Giant viruses are complex members of the virosphere, exhibiting outstanding structural and genomic features. Among these viruses, the pandoraviruses are some of the most intriguing members, exhibiting giant particles and genomes presenting at up to 2.5 Mb, with many genes having no known function. In this work, we analyzed, by virological and microscopic methods, the replication cycle steps of three new pandoravirus isolates from samples collected in different regions of Brazil. Our data indicate that all analyzed pandoravirus isolates can deeply modify the Acanthamoeba cytoplasmic environment, recruiting mitochondria and membranes into and around the electron-lucent viral factories. We also observed that the viral factories start forming before the complete degradation of the cellular nuc

SUBMITTER: Pereira Andrade ACDS 

PROVIDER: S-EPMC6384056 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature