Involvement of a Nonstructural Protein in Poliovirus Capsid Assembly.

ABSTRACT: Virus capsid proteins must perform a number of roles. These include self-assembly and maintaining stability under challenging environmental conditions, while retaining the conformational flexibility necessary to uncoat and deliver the viral genome into a host cell. Fulfilling these roles could place conflicting constraints on the innate abilities encoded within the protein sequences. In a previous study, we identified a number of mutations within the capsid-coding sequence of poliovirus (PV) that were established in the population during selection for greater thermostability by sequential treatment at progressively higher temperatures. Two mutations in the VP1 protein acquired at an early stage were maintained throughout this selection procedure. One of these mutations prevented virion ass

SUBMITTER: Adeyemi OO 

PROVIDER: S-EPMC6384072 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature