Constraints of Viral RNA Synthesis on Codon Usage of Negative-Strand RNA Virus.

ABSTRACT: Negative-strand RNA viruses (NSVs) include some of the most pathogenic human viruses known. NSVs completely rely on the host cell for protein translation, but their codon usage bias is often different from that of the host. This discrepancy may have originated from the unique mechanism of NSV RNA synthesis in that the genomic RNA sequestered in the nucleocapsid serves as the template. The stability of the genomic RNA in the nucleocapsid appears to regulate its accessibility to the viral RNA polymerase, thus placing constraints on codon usage to balance viral RNA synthesis. By in situ analyses of vesicular stomatitis virus RNA synthesis, specific activities of viral RNA synthesis were correlated with the genomic RNA sequence. It was found that by simply altering the sequence and not

SUBMITTER: Gumpper RH 

PROVIDER: S-EPMC6384081 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature