An Extracytoplasmic Function Sigma Factor Controls Cellulose Utilization by Regulating the Expression of an Outer Membrane Protein in Cytophaga hutchinsonii.

ABSTRACT: The common soil cellulolytic bacterium known as Cytophaga hutchinsonii makes use of a unique but poorly understood strategy in order to utilize cellulose. While several genes have been identified as being an active part of the utilization of cellulose, the mechanism(s) by which C. hutchinsonii both (i) senses its environment and (ii) regulates the expression of those genes are not as yet known. In this study, we identified and characterized the gene CHU_3097 encoding an extracytoplasmic function (ECF) σ factor (σ^cel1), the disruption of which compromised C. hutchinsonii cellulose assimilation to a large degree. The σ^cel1 and its putative partner anti-σ^cel1, encoded by the CHU_3096 gene found immediately downstream from

SUBMITTER: Wang X 

PROVIDER: S-EPMC6384103 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature