GABA-modulating bacteria of the human gut microbiota.

ABSTRACT: The gut microbiota affects many important host functions, including the immune response and the nervous system¹. However, while substantial progress has been made in growing diverse microorganisms of the microbiota², 23-65% of species residing in the human gut remain uncultured^3,4, which is an obstacle for understanding their biological roles. A likely reason for this unculturability is the absence in artificial media of key growth factors that are provided by neighbouring bacteria in situ^5,6. In the present study, we used co-culture to isolate KLE1738, which required the presence of Bacteroides fragilis to grow. Bioassay-driven purification of B. fragilis supernatant led to the isolation of the growth factor, which, surprisingly, is the major in

SUBMITTER: Strandwitz P 

PROVIDER: S-EPMC6384127 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature