Association of Serotonin_2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia.

ABSTRACT: There is conflicting evidence for the association between genetic polymorphisms in the serotonin (5-HT)_2C receptor (HTR2C) and response to antipsychotic drugs (APD) in schizophrenic patients. We tested the association between the HTR2C polymorphisms, Cys23Ser, -759C/T, and -697G/C, and response to APDs (mainly clozapine) in a 6 month prospective study in 171 patients with schizophrenia. Ser23 was significantly associated with treatment response (positive symptoms, X ² = 7.540, p = 0.01; negative symptoms, X ² = 4.796, p = 0.03) in male patients only. A -759C-Ser23 haplotype was similar associated with positive (X ² = 6.648, p = 0.01) and negative (X ² = 6.702, p = 0.01) symptom im

SUBMITTER: Li J 

PROVIDER: S-EPMC6384235 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature