Development and Validation of a Prognostic Signature for Malignant Pleural Mesothelioma.

ABSTRACT: Introduction: Dysregulated genes play a critical role in the development and progression of cancer, suggesting their potential as novel independent biomarkers for cancer diagnosis and prognosis. Prognostic model-based gene expression profiles are not widely utilized in clinical medicine. We investigated the prognostic significance of an expression profile-based gene signature for outcome prediction in patients with malignant pleural mesothelioma (MPM). Methods: The gene expression profiles of a large cohort of patients with MPM were obtained and analyzed by repurposing publicly available microarray data. A gene-based risk score model was developed with the training dataset and then validated with the TCGA-MESO (mesothelioma) dataset. The time-dependent receiver operating char

SUBMITTER: Zhou JG 

PROVIDER: S-EPMC6384238 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature