Human Sensory LTP Predicts Memory Performance and Is Modulated by the BDNF Val⁶⁶Met Polymorphism.

ABSTRACT: Background: Long-term potentiation (LTP) is recognised as a core neuronal process underlying long-term memory. However, a direct relationship between LTP and human memory performance is yet to be demonstrated. The first aim of the current study was thus to assess the relationship between LTP and human long-term memory performance. With this also comes an opportunity to explore factors thought to mediate the relationship between LTP and long-term memory. The second aim of the current study was to explore the relationship between LTP and memory in groups differing with respect to brain-derived neurotrophic factor (BDNF) Val⁶⁶Met; a single-nucleotide polymorphism (SNP) implicated in memory function. Methods: Participants were split into three genotype groups (V

SUBMITTER: Spriggs MJ 

PROVIDER: S-EPMC6384276 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature