Correlation between FMISO-PET based hypoxia in the primary tumour and in lymph node metastases in locally advanced HNSCC patients.

ABSTRACT:

Purpose

This secondary analysis of the prospective study on repeat [¹⁸F]fluoromisonidazole (FMISO)-PET in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) assessed the correlation of hypoxia in the primary tumour and lymph node metastases (LN) prior to and during primary radiochemotherapy.

Methods

This analysis included forty-five LN-positive HNSCC patients having undergone FMISO-PET/CTs at baseline, and at week 1, 2 and 5 of radiochemotherapy. The quantitative FMISO-PET/CT parameters maximum standardised uptake value (SUV_max, corrected for partial volume effect) and peak tumour-to-background ratio (TBR_peak) were estimated in the primary tumour as well as in index and large LN, respectively. Statistical analysis wa

SUBMITTER: Bandurska-Luque A 

PROVIDER: S-EPMC6384311 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature