Outcomes Following Macrolide Use in Kidney Transplant Recipients.

ABSTRACT:

Background

Calcineurin inhibitors (CNI; cyclosporine, tacrolimus) are critical for kidney transplant immunosuppression, but have multiple potential drug interactions, such as with macrolide antibiotics. Macrolide antibiotics (clarithromycin, erythromycin, and azithromycin) are often used to treat atypical infections. Clarithromycin and erythromycin inhibit CNI metabolism and increase the risk of CNI nephrotoxicity, while azithromycin does not.

Objective

To determine the frequency of CNI-macrolide co-prescriptions, the proportion who receive post-prescription monitoring, and the risk of adverse drug events in kidney transplant recipients.

Design

Retrospective cohort study.

Setting

We used linked health care databases in Alberta, Canada.

Patients

We includ

SUBMITTER: Jeong R 

PROVIDER: S-EPMC6385328 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature