Odorant ligands for the CO₂ receptor in two Anopheles vectors of malaria.

ABSTRACT: Exhaled CO₂ is an important host-seeking cue for Anopheles mosquitoes, which is detected by a highly conserved heteromeric receptor consisting of three 7-transmembrane proteins Gr22, Gr23, and Gr24. The CO₂ receptor neuron has been shown to also respond sensitively to a variety of odorants in Aedes aegypti. The detection of CO₂ is important for upwind navigation and for enhancing the attraction to body heat as well as to skin odorants. The orthologs of the CO₂ receptor proteins are present in malaria-transmitting mosquitoes like Anopheles coluzzii and Anopheles sinensis. Activators and inhibitors of the CO₂-neuron were tested on the maxillary palps in these two species by single-sensillum electrophysiology. The electrophysiological tes

SUBMITTER: Coutinho-Abreu IV 

PROVIDER: S-EPMC6385339 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature