Type 3 inositol 1,4,5-trisphosphate receptor has antiapoptotic and proliferative role in cancer cells.

ABSTRACT: Although the involvement of type 1 (IP₃R1) and type 2 (IP₃R2) inositol 1,4,5-trisphosphate receptors in apoptosis induction has been well documented in different cancer cells and tissues, the function of type 3 IP₃R (IP₃R3) is still elusive. Therefore, in this work we focused on the role of IP₃R3 in tumor cells in vitro and in vivo. We determined increased expression of this receptor in clear cell renal cell carcinoma compared to matched unaffected part of the kidney from the same patient. Thus, we hypothesized about different functions of IP₃R3 compared to IP₃R1 and IP₃R2 in tumor cells. Silencing of IP₃R1 prevented apoptosis induction in colorectal cancer DLD1 cells, ovarian cancer A2780 ce

SUBMITTER: Rezuchova I 

PROVIDER: S-EPMC6385365 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature