Association of high Plasmodium falciparum parasite densities with polyclonal microscopic infections in asymptomatic children from Toubacouta, Senegal.

ABSTRACT:

Background

Malaria is a leading cause of mortality and morbidity in tropical countries, especially in sub-Saharan Africa. In Senegal, a control plan implemented in the beginning of the 2000s has enabled a substantial reduction of mortality and morbidity due to malaria. However, eradication of malaria requires a vaccine that protects against Plasmodium falciparum the deadliest species of the parasite that causes this disease. Plasmodium falciparum is characterized by an extensive genetic diversity that makes vaccine development challenging. In this study, the diversity of P. falciparum isolates was analysed from asymptomatic children residing in the district of Toubacouta, Senegal.

Methods

A nested PCR approach was used to perform genotyping of the msp-1 and msp-2 loci in sam

SUBMITTER: Diouf B 

PROVIDER: S-EPMC6385392 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature