The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles.

ABSTRACT:

Background

The periodic growth of hair follicles is regulated by the balance of activators and inhibitors. The BMP signaling pathway plays an important role during hair follicle regeneration, but the exact BMP protein that controls this process has not been revealed.

Methods

The expression of BMP6 was determined via in situ hybridization and immunofluorescence. The in vivo effect of BMP6 overexpression was studied by using a previously established adenovirus injection model. The hair follicle regeneration was assessed by gross observation, H&E staining and 5-bromo-2-deoxyuridine (BrdU) tracing. The expression patterns of BMP6 signaling and Wnt10b signaling in both AdBMP6-treated and AdWnt10b-treated skins were determined by in situ hybridization and immunofluorescence.

Re

SUBMITTER: Wu P 

PROVIDER: S-EPMC6385416 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature