Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients.

ABSTRACT:

Background

Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to determine the relationship between serum klotho and cerebrovascular disease in patients receiving hemodialysis.

Methods

Serum klotho levels of hemodialysis patients were measured by ELISA. Cerebrovascular diseases were diagnosed by CT or MRI scans. The cognitive function of hemodialysis patients with cerebrovascular disease were evaluated with a neuropsychological battery assessing domains of global cognition verbal memory, spatial memory, executive function and verbal fluency.

Results

SUBMITTER: Wei H 

PROVIDER: S-EPMC6385422 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature