Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau.

ABSTRACT:

Background

Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ₄₂, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals.

Methods

One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ₄₂, P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time.

Results

Spindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF Aβ₄₂, P-tau and T-tau. From the three, CSF T-tau was the most significantly associated with sp

SUBMITTER: Kam K 

PROVIDER: S-EPMC6385427 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature