A mathematical model of iron import and trafficking in wild-type and Mrs3/4ΔΔ yeast cells.

ABSTRACT:

Background

Iron plays crucial roles in the metabolism of eukaryotic cells. Much iron is trafficked into mitochondria where it is used for iron-sulfur cluster assembly and heme biosynthesis. A yeast strain in which Mrs3/4, the high-affinity iron importers on the mitochondrial inner membrane, are deleted exhibits a slow-growth phenotype when grown under iron-deficient conditions. However, these cells grow at WT rates under iron-sufficient conditions. The object of this study was to develop a mathematical model that could explain this recovery on the molecular level.

Results

A multi-tiered strategy was used to solve an ordinary-differential-equations-based mathematical model of iron import, trafficking, and regulation in growing Saccharomyces cerevisiae cells. At the simplest l

SUBMITTER: Wofford JD 

PROVIDER: S-EPMC6385441 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature