Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review.

ABSTRACT:

Background

The association of ABO blood groups with gastric cancer risk was proposed decades ago, but the results have been inconsistent.

Methods

We used two single nucleotide polymorphisms to determine ABO genotype in 4932 gastric cancer cases and 6158 controls of Chinese descent, and evaluated the associations of ABO blood groups and genotypes with risk of gastric cancer using multivariable logistic regression models. We also systematically reviewed published literature and performed a meta-analysis of all relevant studies.

Results

In the case-control study, compared with blood group O, both blood group A and AB were associated with increased gastric cancer risk (for group A, odds ratio (OR) = 1.13, 95% confidence interval (CI): 1.02-1.24; for group AB, OR = 1.18, 9

SUBMITTER: Mao Y 

PROVIDER: S-EPMC6385454 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature